An overview on its metal homeostatic regulation in. These proteins are expressed by astrocytes, and their expression is. Metallothionein is one of the most powerful antioxidants that the human body produces. Metallothionein in human oesophagus, barretts epithelium and adenocarcinoma article pdf available in british journal of cancer 875. Metallothionein mt melothionin heavy metal toxicity a protein see also the definition of methylation a medical condition that is similar. If you have ocb, diabetes, neuropathy, immune problems, candia, brain problems, brain swelling, headaches, autism, learning difficulties, brest cancer, cancer, ms or als you must study this page. Neuroprotective and neuroregenerative properties of metallothioneins. Sconfiguration with extraordinary metalbinding capability. Metallothioneins mts are intracellular, low molecular, low molecular weight, cysteinerich proteins. The role of metallothionein in oxidative stress mdpi.
Metallothioneins mts are small cysteinerich proteins that play important roles in metal. Kidney beans and other legumes are a major source of food in latin america, while lentils, pigeon peas, and chickpeas are important in south asia. Ubiquitous in eukaryotes, mts have unique structural characteristics to give potent metalbinding and redox capabilities. Metallothionein mt is a small, cysteinerich protein that plays a role in metal homeostasis. Nutritionally, legume seeds are two to three times richer in protein than cereal grains.
The biologic function of metallothionein mt has been a perplexing topic ever since the discovery of this protein. The induction of mt expression is induced through metal regulatory transcription factor 1 mtf1, a 753 amino acid transcription factor, which directly responds to increased levels of free zincii 62. Metallothionein mt is a ubiquitous protein with a low molecular weight of 67 kda weight and it was first identified. Ubiquitous in eukaryotes, mts have unique structural. But it is one that doesnt get a lot of mainstream press, and its somewhat complex in its functions.
Metallothionein genes encoding ros scavenging enzymes are. Metallothionein causes cancer, diabetes, oxidative stress. Presenilin2 proteins that lie at the catalytic centre of the. Structural similarity of entire sequence or large sequence fragment enables prediction and modeling of entire structural domain, while distribution of local features of known protein structure. Some legumes, such as soybeans and peanuts, are also rich in oil. Within the antioxidant and antiaging world, there has been more emphasis on glutathione and other antioxidants such as lipoic acid, coq10 and sod.
Zincii itself causes an increase in the major zincbinding protein metallothionein. Pdf the role of metallothionein in oxidative stress. Many studies have suggested that mt plays a role in the homeostasis of essential metals such as zinc and copper, detoxification of toxic metals such as cadmium, and protection against oxidative stress. The native copper and zinc binding protein metallothionein. A primary role has not been identified, and remains elusive, as further functions continue to be discovered. Metallothioneins mts are lowmolecular weight cysteine and metal rich proteins with unquestionable metal binding capacity, antioxidant and. The roles of metallothioneins in carcinogenesis journal of. Metallothioneins mts are the major endogenous zinc and copper binding. Metallothioneins are multipurpose neuroprotectants during brain.
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